Hbv Life Cycle
نویسنده
چکیده
Globally, WHO estimates that 350 million individuals are infected with HBV and that HBV is endemic in sub-Saharan Africa and regions of Asia. Hepatitis B is a major risk factor for hepatocellular carcinoma. Hepatitis B is treated with oral nucleoside reverse transcriptase inhibitors. Bolognese J. Hepatitis B Virus and Hepatocellular Carcinoma. Med J Therapeut Africa. 2007;3:229-3.
منابع مشابه
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
Hepatitis B virus (HBV) infection is a globally distributed health problem. The number of carriers of HBV is estimated to exceed 240 million people worldwide. Compared with uninfected individuals, HBV carriers have an increased risk of developing hepatocellular carcinoma. The prevention of HBV infection is therefore strongly recommended, and a HBV vaccine is available. For carriers, treatment w...
متن کاملInvestigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses
Chronic infection with hepatitis B virus (HBV) increases the risk of developing fibrosis, cirrhosis or hepatocellular carcinoma. Current therapies are limited to type-I interferons and/or nucleos(t)ide analogues; however, these are only partially effective. The development of novel anti-HBV agents for new treatment strategies has been hampered by the lack of a suitable system that allows the in...
متن کاملGenome-Wide Transcriptome Analysis of CD36 Overexpression in HepG2.2.15 Cells to Explore Its Regulatory Role in Metabolism and the Hepatitis B Virus Life Cycle
Hepatitis B virus (HBV) is a hepatocyte-specific DNA virus whose gene expression and replication are closely associated with hepatic metabolic processes. Thus, a potential anti-viral strategy is to target the host metabolic factors necessary for HBV gene expression and replication. Recent studies revealed that fatty acid translocase CD36 is involved in the replication, assembly, storage, and se...
متن کاملNovel reporter system to monitor early stages of the hepatitis B virus life cycle
A recombinant hepatitis B virus (HBV) expressing NanoLuc (NL) (HBV/NL) was produced by cotransfecting a plasmid containing a 1.2-fold HBV genome carrying the NL gene with a plasmid bearing a packaging-defective 1.2-fold HBV genome into a human hepatoma cell line, HepG2. We found that NL activity in HBV/NL-infected primary hepatocytes or sodium taurocholate cotransporting polypeptide-transduced ...
متن کاملStudy of the early steps of the Hepatitis B Virus life cycle
Hepatitis B virus (HBV) is a human pathogen, causing the serious liver disease. Despite considerable advances in the understanding of the natural history of HBV disease, most of the early steps in the virus life cycle remain unclear. Virus attachment to permissive cells, fusion and penetration through cell membranes and subsequent genome release, are largely a mystery. Current knowledge on the ...
متن کاملHepatitis B Virus-Specific miRNAs and Argonaute2 Play a Role in the Viral Life Cycle
UNLABELLED Disease-specific serum miRNA profiles may serve as biomarkers and might reveal potential new avenues for therapy. An HBV-specific serum miRNA profile associated with HBV surface antigen (HBsAg) particles has recently been reported, and AGO2 and miRNAs have been shown to be stably associated with HBsAg in serum. We identified HBV-associated serum miRNAs using the Toray 3D array system...
متن کامل